Applications Overview

As part of the Boston University Center of Synthetic Biology, our wetlab team conducts research into the design and construction of synthetic biological systems, with particular focus on the development of tools for engineering novel biological devices in E. coli.

Wetlab researchers also work closely with programmers and engineers to test and evaluate our design automation tools. These real-world applications are essential to making our software effective and relevant to creating new workflows for biological engineering, making this feedback an integral part of our development process.

Want to know more? Check out our current synthetic biology projects.

Cyber-physical systems are networks of elements which interact with the physical environment through various input and output mechanisms. Because of the nature of this interaction, communication, coordination, and computation must interact closely during the design and development process of these systems.

The aim is to synthesize desired behaviors in populations of bacterial and mammalian cells. To this goal, we define the basis of a next-generation CPS called biological CPS (bioCPS). The enabling technologies are synthetic biology and micron-scale mobile robotics. Synthetic gene circuits for decision making and local communication among the cells are automatically synthesized using a Bio-Design Automation workflow. A Robot Assistant for Communication, Sensing, and Control in Cellular Networks, which is designed and built as part of this project, is used to generate desired patterns in networks of engineered cells.
This Frontier CPS project combines control, formal methods, synthetic biology, robotics, and design automation. It develops novel formal methods and control theoretic approaches to pattern synthesis andBio-Design Automation. It defines new building blocks for bioCPS
in the form of robotic technology and synthetic circuits for control, communication, and sensing.

You can read more about this at:

New cyber-physical systems projects are coming soon.

The first step in creating a microfluidic platform for distributed biological computation is to build the necessary framework and tools to allow for easy iteration and refinement of microfluidic design while taking into account the biological components.

The various projects under the microfluidics umbrella are a confluence of multi-disciplinary research spanning across manufacturing, embedded electronics and CAD tool development.

Want to know more? Check out our current Microfluidics projects.